In this paper, quadratic and sextic B-splines are used to construct an approximating function based on the integral values instead of the function values at the knots. This process due to the type of used B-splines (fourth order or sixth order), called integro quadratic or sextic spline interpolation. After introducing the integro quartic and sextic B-spline interpolation, their convergence is discussed. The interpolation errors are studied. Numerical results illustrate the efficiency and effectiveness of the new interpolation method.